Aspirin and Calcium as a preventive therapy of earlyand late preeclampsia

Abstract

Preeclampsia and fetal growth restriction are major causes of perinatal death and handicap in survivors. Indications for aspirin during pregnancy are a matter of debate. The optimum dosage, from 75mg/day to 150mg/day, needs to be determined. The aim of the research was to estimate the impact of low-dose aspirin and calcium on prevention of preeclampsia. During the research there was conducted a prospective analysis of the effectiveness of aspirin and calcium in pregnant women with preeclampsia from VMCM hospital №1, in a period from 2016 till 2018. 88 women participated, they were divided into two investigated groups: I - 36 women with early preeclampsia (EP), and II group - 52 women with late preeclampsia (LP). In EP group 28 women were taking aspirin in dose of 75 mg, in LP - 36. Also, in EP group 12 women were taking low doses of calcium (<1g/day), and 26 in LP group (tab. 1). Main diagnostically significant indexes were determined, which later underwent comparative analysis for all groups. Statistical processing of the obtained results was performed by odds ratio, its standard error and 95% confidence interval were calculated according to Altman, 1991. We didn't define significant preventive differences in preeclampsia phenotype compared subgroups. Aspirin in dose of 75 mg/day and Calcium <1g/day is ineffective, also taking to account irregular intake - for 4-5-6 times per week. Preventive therapy requires definite period of beginning - 12 weeks of gestation and systemic everyday intake of drugs. In future, we need to explore a perfect dose of aspirin and calcium supplementation to prevent preeclampsia and hypertensive disorders in pregnancy.