International severe warning requirements and smart decisions in choice tactics for fluoroquinolones

Abstract

Fluoroquinolones occupy one of the leading places when using worldwide. However, the range of adverse reactions at post-marketing levels is expanding, that requires attention and restrictions. The specified list of adverse reactions in the instructions for the drugs is supplemented by a great attention to disorders of the nervous system, joints and the risk of rupture of aortic aneurysm. Additional indications comprise: elderly patients, previous history of reactions to fluoroquinolones, renal or joint dysfunction, interaction with glucocorticoids. These limitations must be taken into account by physicians in daily practice.