Антимікробна дія антисептичних препаратів на клінічні штами мікроорганізмів, що контамінують бойові поранення кінцівок

Abstract

Abstract. The article deals with the role of antiseptics in military wounds treatment connected with the emergence of a significant number of multi–drug resistant strains of microorganisms. Local application of antiseptics for prevention and treatment of wounds’ infections looks promising. The purpose of the study was to evaluate the efficiency of modern antiseptics against microorganisms allocated in combat injuries. Sensitivity of microorganisms to antiseptics (Decamethoxin, Benzalkonium Chloride, Miramistin, Chlorhexidine Digluconate, Polyhexamethylene Guanidine, Octenidine, and Iodine–Povidone Hydrogen Peroxide) was examined by serial double dilutions. Minimal bactericidal concentration was used for assessment of sensitivity to the drugs. The qualitative slurry test determined the exposure time needed for the complete destruction of the clinical strains. Tested drugs concentration was sufficient to achieve stagnation effect. Susceptibility levels of investigated microorganisms to antiseptics were significantly lower than antiseptics concentrations usually used in practice. The slurry qualitative tests have shown that any of the antiseptics can lead to the complete destruction of microbial cultures by increasing the time of direct exposure. In order to achieve an effective impact on microorganisms it is necessary to use techniques that provide sustained release of the antiseptic in a wound.