Ототоксичність лікарських засобів

Жамба, A. O.; Zhamba, A. O.

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dc.contributor.author	Жамба, A. O.	uk
dc.contributor.author	Zhamba, A. O.	en
dc.date.accessioned	2018-03-27T10:32:13Z
dc.date.available	2018-03-27T10:32:13Z
dc.date.issued	2015
dc.identifier.citation	Жамба А. О. Ототоксичність лікарських засобів / А. О. Жамба // Вісник проблем біології і медицини. – 2015. – Вип. З, т. 1. – С. 40-44.	uk
dc.identifier.issn	2077-4214
dc.identifier.uri	https://dspace.vnmu.edu.ua/123456789/2218
dc.description	The article is devoted to the problem of ototoxic drugs. Hearing problems can cause more than 130 medications, they are called ototoxic. Ototoxicity - a harmful effect of drugs and other chemicals on the organ of hearing and /or vestibular system, which is accompanied by worsening or loss of hearing and balance disorders. Ototoxic effects of drugs are the destructive effect on sensitive cells (neurons) of the inner ear and auditory nerve. Signs and symptoms from ototoxic drug action are indicated. Groups of drugs and certain drugs, including antibiotics and macrolides aminoglycoside, loop diuretics, NSAIDs, cytostatics, anti-ТВ drugs thatare ototoxiccare listed. Various mechanisms of ototoxicity and destruction of certain structures of ears depending on certain groups of drugs are described. Risk patients and risk factors that contribute to manifestations of ototoxicity are indicated. When used ototoxic drugs should take into account their pharmacokinetics. It was established that the concentration of antibiotics in fluids of the inner ear grows slowly but reaches very high concentrations that exceed its level in the blood, and kept for a longtime. Characteristically, the lesions of organ of hearing and balance by drugs are most common in patients with impaired renal excretory function, as the elimination of ototoxic drugs occurs mainly through the kidneys. It should be noted that ototoxic drugs are also nephrotoxic. A possible explanation is similarity of functions of vascular epithelium strips and renal tubules that support electrochemical gradients. However, renal tubular epithelium is able to regenerate, while damage of hair cells and vascular strips in organ of hearing is often irreversible. Cases of congenital deafness in children whose mothers used ototoxic drugs during pregnancy were registered. Ability of certain ototoxic drugs to penetrate the placenta and reach in the fetus blood higher concentration than in maternal blood is very important in such situations. An important pathogenetic factor is the features of the kidneys function during pregnancy (endocrine and mechanical influences) and kidney diseases in pregnant women. Consequently, pregnancy is a major contraindication to the use of ototoxic drugs. Thus, doctor should assess benefits and risks of drugs, and at pharmacotherapy of pregnant women and children- should renounce the use of ototoxic drugs. Its usage can be able only in cases of threats to the life of the patient, when these drugs cannot be replaced by others. In this case, pharmacotherapy should be performed only in a hospital, under conditions: monitoring of renal function and serum blood drug level; monitoring of hearing on high frequencies (8-20 kHz) and the possibility of using, if necessary, registration of induced auditory potentials. To assess the quality of life of the patient should use criteria for assessing of functional impairment at ototoxic lesions of the inner ear due to International Classification of organism functions developed by WHO. The use of ototoxic drugs requires a strict medical supervision, monitoring, prevention and accounting. The patient should be informed of the possibility of ototoxic drug influence, about alternative methods of treatment and must give written consent to its application.	en
dc.description.abstract	Стаття присвячена проблемі ототоксичності лікарських засобів (ЛЗ). Ототоксичний ефект ЛЗ полягає в руйнівній дії препаратів на чутливі клітини (нейрони) внутрішнього вуха і слуховий нерв. Вказані прояви та симптоматика ототоксичнї дії препарату. Переховані групи препаратів та окремі ЛЗ, зокрема антибіотики з % групи аміноглікозидів та макролідів, петльові діуретики, НПЗЛЗ, цитостатики, протитуберкульозні ЛЗ, які діють ототоксично. Описані різні механізми розвитку ототоксичності та ураження певних структур вуха в залежності від конкретних груп препаратів. Вказані групи ризику пацієнтів та фактори ризику, які сприяють проявам ототоксичності. Застосування ототоксичних препаратів потребує суворого медичного контролю, моніторингу, профілактики та обліку.	uk
dc.language.iso	uk_UA	uk
dc.subject	ототоксичність	uk
dc.subject	лікарські засоби	uk
dc.subject	слуху зниження	uk
dc.subject	ототоксичность	ru
dc.subject	лекарственные средства	ru
dc.subject	слуха снижение	ru
dc.subject	ototoxicity	en
dc.subject	hearing loss	en
dc.title	Ототоксичність лікарських засобів	uk
dc.title.alternative	Ототоксичность лекарственных средств	ru
dc.title.alternative	Drug-Induced Ototoxicity	en
dc.type	Article	en