Comparison of cerebroprotective action of mesenchymal stromal cells of different origin and lysate from human Wharton jelly MSC in post-perfusion lesion of the sensorimotor cortex of rats

Abstract

One of the main causes of stroke in acute cerebrovascular accident is ischemia, which begins with the formation of acute neuronal energy deficiency with subsequent activation of "ischemic cascade" reactions, which leads to irreversible damage in nerve tissue. But the restoration of perfusion of ischemic tissue contributes to the deepening of metabolic disorders in the brain, which leads to the formation of reperfusion damage. In view of this, it was expedient to characterize and compare the effect of different origin mesenchymal stromal cells (MSC) and lysate from human Warton jelly (WJ) MSC on neuroapoptotic changes in the sensorimotor cortex of rats in the conditions of model ischemia-reperfusion (IR) by flow cytometry - one of the best methods for assessing the fragmentation of neuronal DNA.