Discriminant models of the possibilities of occurrence and featuresof the course of benign nevi in men depending on thecharacteristics of dermatoscopic parameters

Abstract

Human skin is the first barrier to protect the body from external factors. Combinationsof certain external and internal (genetically determined) factors can lead to cancer ofthis organ. One of such pathologies is nevi - still little studied disease. At the sametime, modern medicine is interested in inventing mechanisms to predict their occurrenceand course. The purpose of the study is to build and analyze discriminant models of thepossibility of benign nevi in Ukrainian men depending on the characteristics ofdermatoscopic parameters. Ukrainian men aged 22 to 35 years, patients with melanocytebenign simple nevi (n=34), melanocyte benign dysplastic nevi (n=27), melanocytebenign congenital nevi (n=14) and non-melanocyte benign nevi (n=17) get dermatoscopicexamination. The possibility of benign nevi occurrence depending on the characteristicsof dermatoscopic parameters was carried out using discriminant analysis in the licensedstatistical package "Statistica 5.5". With the help of discriminant analysis, reliablemodels of the possibility of occurrence of benign nevi depending on the characteristicsof dermatoscopic parameters are built. It was found that among patients with melanocytebenign simple, dysplastic, congenital and non-melanocyte benign nevi, a reliableinterpretation of the obtained classification indicators is possible (discriminant functioncovers 70.7 % of cases; statistics Wilks' Lambda=0.185; p<0.001). The models includethe general dermatoscopic index, the dermatoscopic criterion "Asymmetry" accordingto the ABCD system, the number of nevi on the body more than 1 cm and thedermatoscopic criterion "Color" according to the ABCD system. Moreover, the generaldermatoscopic index and the dermatoscopic criterion "Asymmetry" according to theABCD system make the greatest contribution to discrimination between Ukrainian menwith benign nevi