Перегляд Кафедра біохімії ім. професора О. О. Пентюка за темою "breast cancer"

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Influence of CYP2D6 and its polymorphic forms on the metabolism of tamoxifen in therapy of luminal forms of breast cancer

Yurchenko, P. O.; Shkarupa, V. M.; Kakarkin, O. Y.; Kovalchuk, A. P.; Kovalchuk, B. A.; Pechevystiy, O. M.; Filchukov, D. O.; Kachula, S. O. (Reports of Vinnytsia National Medical University, 2024)

Tamoxifen belongs to the group of selective estrogen receptor modulators (SERM) and is metabolized by the detoxification system of xenobiotics, and the phenomenon of metabolic activation can be observed at the first stage. ...
Influence of polymorphism of enzymes of the UDP family-glucuronyl transferases on the biotransformation of tamoxifen in the therapy of luminal forms of breast cancer

Yurchenko, P. O.; Shkarupa, V. M.; Kachula, S. O.; Kakarkin, O. Y.; Kovalchuk, A. P.; Kovalchuk, B. P.; Pechevystiy, O. M.; Filchukov, D. O. (Reports of Vinnytsia National Medical University, 2023)

Tamoxifen (TAM) (1-[4-(2-dimethylaminoethoxy)-phenyl]-1,2-diphenylbut-1(Z)-ene) is a non-steroidal selective estrogen receptor modulator (SERM), which is recognized as the "gold standard" of hormone therapy for estrogen-dependent ...

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