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dc.contributor.author Zaichko, K. en
dc.contributor.author Gumeniuk, O. en
dc.contributor.author Stanislavchuk, M. en
dc.date.accessioned 2020-03-13T07:27:07Z
dc.date.available 2020-03-13T07:27:07Z
dc.date.issued 2018
dc.identifier.citation Zaichko K. Urinary 6-sulfatoxymelatonin excretion and galectin-3 plasma level in patients with osteoarthritis / K. Zaichko, O. Gumeniuk, M. Stanislavchuk // Annals of the Rheumatic Diseases / EULAR (Amsterdam). – 2018. – Vol. 77, suppl. 2. – Р. 797. en
dc.identifier.uri https://dspace.vnmu.edu.ua/123456789/4489
dc.description.abstract Melatonin and galectin-3 are considered as factors in the development of immune-inflammatory and destructive changes in joints. To study the excretion of 6-sulfatexymelatonin and galectin-3 level in the blood and evaluate their association with the clinical manifestation and life quality in patients with osteoarthritis (OA) were investigated 141 patients with OA of knee joints (76.6% women), aged 58.4±7.91 years, duration of the disease 10.5±6.50 years. It was established in patients with OA a decrease in 6-SMT excretion (mean 25.3 vs 38.8 ng/mg creatinine in control). 6-SMT excretion correlated with age and was more significant in patients with knee +hip OA (mean 26.5 vs 23.0  ng/mg creatinine in patients with OA of the knee only). Lower levels of 6-SMT excretion associated with higher pain and with lower quality of life. Lower levels of melatonin and higher of galectin-3 were associated with higher WOMAC index and poorer quality of life in patients with OA. This association may reflect possible pathogenic role of melatonin and galectin-3 in OA. en
dc.language.iso en en
dc.subject osteoarthritis en
dc.subject 6-sulfatoxymelatonin en
dc.subject galectin-3 en
dc.subject melatonin en
dc.subject creatinine en
dc.subject knee joints en
dc.title Urinary 6-sulfatoxymelatonin excretion and galectin-3 plasma level in patients with osteoarthritis en
dc.type Thesis en


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