Investigation of toll-like receptor levels in patients with respiratory infections with individualized infusion and antimicrorial management

Abstract

The aim of the study is to evaluate the dynamics of TLR-4 levels and microbial colonization in patients with infectious respiratory complications with different treatment strategies. Materials and Methods. 20 children in each group with different approaches to treatment - in the main observation group in the complex of antimicrobial treatment at the same time with empirically prescribed standard antibiotic therapy we used inhalation of quaternary ammonium compound (decamethoxine) through a nebulizer from the appearance of clinical signs of VAP, and the treatment of patients in the control group was carried out in accordance with generally accepted recommendations with the use of systemic antibacterial and symptomatic therapy. Results. It was found that the level of TLR-4 in the serum clearly correlates with the dynamics of the infectious process and the microbiological status of patients. Conclusions. The determination of the level of TLR-4 can serve as a diagnostic criterion for the development of severe bacterial disease and evaluate the effectiveness of the selected treatment regimen (Fig. 6, Ref. 60).