The influence of the course infusion of ademol on the pool of adenyl nucleotides and intermediates of carbohydrate Exchange in the brain of rats with traumatic brain injury

Abstract

The high expectations of modern medicine for neuroprotective therapy have encouraged scientists around the world to actively seek for new effective drugs. The effectiveness of neuroprotective agents is largely determined by their ability to normalize the metabolism of adenyl nucleotides and the associated biochemical processes in the brain. The aim of the study was to evaluate the magnitude of the cerebroprotective effect of ademol with the possibility of correcting the changes in the pool of adenyl nucleotides and carbohydrate metabolism intermediates in the brain of rats with experimental traumatic brain injury. The experimental model of severe trauma was caused by the action of a carbon dioxide flow under pressure, which was created with a gas-balloon air pistol. The therapeutic effect of ademol on model of traumatic brain injury was evaluated at a dose of 2 mg/kg i/v. The 8-days infusion of ademol solution in rats with traumatic brain injury at a conditionally effective cerebroprotective dose (2 mg/kg i/v) was more effective (p<0.05) than the use of amantadine sulfate (5 mg/kg i/v) and inhibited the hyperactivation of anaerobic glycolysis, stimulated tissue respiration, reduced the signs of lactic acidosis and the development of the secondary alteration of brain cells by deoxidized products.