Elevated serum TLR4 level as a potential marker for postsurgical chronic pain in pediatric patients with different approaches to analgesia

Semkovych, Y.; Dmytriiev, D.

dc.contributor.author	Semkovych, Y.	en
dc.contributor.author	Dmytriiev, D.	en
dc.date.accessioned	2025-03-28T08:32:57Z
dc.date.available	2025-03-28T08:32:57Z
dc.date.issued	2022
dc.identifier.citation	Semkovych Y. Elevated serum TLR4 level as a potential marker for postsurgical chronic pain in pediatric patients with different approaches to analgesia / Y. Semkovych, D. Dmytriiev // Frontiers in Medicine. – 2022. – Vol. 9. – P. 1–10.	en
dc.identifier.uri	https://dspace.vnmu.edu.ua/123456789/9240	en
dc.description.abstract	The perioperative period of any surgery is accompanied by immune suppression. The level of Toll-like receptor 4 (TLR4) is known to increase in inflammation and after nerve injury and contributes to the development of neuropathic pain. The interaction of TLRs in response to the eect of opioids results in paradoxical hyperalgesia. Regional anesthesia techniques are the standard of care for perioperative pain management in children. Aim: The aim of the study was to determine and evaluate the indicators of TLR4 for different methods of pain relief in anesthetic management of hernia repair in children and their eect on pain chronification.	en
dc.language.iso	en	en
dc.publisher	Frontiers in Medicine	en
dc.subject	pain	en
dc.subject	chronic pain	en
dc.subject	Toll-like receptor 4	en
dc.subject	children	en
dc.subject	regional anesthesia	en
dc.title	Elevated serum TLR4 level as a potential marker for postsurgical chronic pain in pediatric patients with different approaches to analgesia	en
dc.type	Article	en