Репозиторій Вінницького національного медичного університету імені М. І. Пирогова

Investigation of Toll-like receptor 4 levels in patients with respiratory infections with individualized infusion and antimicrobial management

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dc.contributor.author Nazarchuk, O
dc.contributor.author Melnichenko, M
dc.contributor.author Dmytriiev, D
dc.contributor.author Bahniuk, N
dc.contributor.author Levchenko, B
dc.contributor.author Grebeniuk, D
dc.contributor.author Dudar, A
dc.contributor.author Dobrovanov, O
dc.date.accessioned 2025-03-24T13:06:44Z
dc.date.available 2025-03-24T13:06:44Z
dc.date.issued 2023
dc.identifier.citation Investigation of Toll-like receptor 4 levels in patients with respiratory infections with individualized infusion and antimicrobial management / O. Nazarchuk, M. Melnychenko, D. Dmytriiev [et al.] // Lekársky Obzor. – 2023. – №72(6). – P. 260-267. uk_UA
dc.identifier.uri https://dspace.vnmu.edu.ua/123456789/8950
dc.description.abstract The aim of the study is to evaluate the dynamics of TLR-4 levels and microbial colonization in patients with infectious respiratory complications with different treatment strategies. Materials and Methods. 20 children in each group with different approaches to treatment - in the main observation group in the complex of antimicrobial treatment at the same time with empirically prescribed standard antibiotic therapy we used inhalation of quaternary ammonium compound (decamethoxine) through a nebulizer from the appearance of clinical signs of VAP, and the treatment of patients in the control group was carried out in accordance with generally accepted recommendations with the use of systemic antibacterial and symptomatic therapy. Results. It was found that the level of TLR-4 in the serum clearly correlates with the dynamics of the infectious process and the microbiological status of patients. Conclusions. The determination of the level of TLR-4 can serve as a diagnostic criterion for the development of severe bacterial disease and evaluate the effectiveness of the selected treatment regimen. uk_UA
dc.language.iso en uk_UA
dc.publisher Lekársky Obzor uk_UA
dc.subject VAP uk_UA
dc.subject children uk_UA
dc.subject toll-like receptors 4 uk_UA
dc.subject quaternary ammonium compound uk_UA
dc.subject decametoxine uk_UA
dc.title Investigation of Toll-like receptor 4 levels in patients with respiratory infections with individualized infusion and antimicrobial management uk_UA
dc.type Article uk_UA


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