Assessment of the effect of various cerebroprotectors on the dynamics of cerebral and central hemodynamics in traumatic brain injury in rats

Abstract

Now the issue regarding the choice of effective cerebroprotective agents for traumatic brain injury (TBI) remains insufficiently studied.Aim. To assess the effect of using the adamantane derivative 1-adamantylethyloxa-3-morpholino-2-propanol hydrochloride (Ademol) compared with amantadine sulfate and 0.9 % NaCl solution on the state of cerebral and central hemodynamics in rats with acute TBI.Materials and methods. The therapeutic effect of Ademol on experimental TBI was assessed using a dose of 2 mg/kg intravenously (i/v) every 12 hours for 8 days. The pseudo-operated animals and the control group received 0.9 % NaCl solution at a dose of 2 ml/kg i/v, and the comparison group received amantadine sulfate at a dose of 5 mg/kg in the same regimen. To determine the effectiveness of the studied drugs in brain injury, the following indicators were used: central venous pressure (CVP), volumetric rate of cerebral circulation (VRCC) and blood pressure (BP).Results. The 8-day use of Ademol indicates not only the best efficacy of this drug compared with the control group and amantadine sulfate by 76.2 % and 34.8 % (P < 0.05), respectively, but also the absence of a significant difference between the dynamics of VRCC in the Ademol group and the baseline on the 8th day of observation. Ademol administration in rats was significantly more effective and resulted in BP stabilization within the background values during the entire observation period, and from the 4th day, the BP level in the Ademol group did not differ from the group of pseudo-op-erated animals (baseline). Therapy of modeled TBI with NMDA receptor blockers resulted in the stabilization of CVP, although in addition to Ademol, unlike amantadine sulfate, the studied parameter did not differ significantly from the background values in all periods of the experiment.Conclusions. The course of treatment in rats with severe TBI with Ademol solution at a dose of 2 mg/kg i/v is probably better helps to maintain cerebral blood flow and prevents a drop in one of the main indicators of central hemodynamics (BP and CVP) (P < 0.05) than that in rats of the control pathology group with 0.9 % NaCl and the amantadine sulfate group.