Correction of dysbiosis and elimination of inflammation of the oral cavity in patients with malignant tumors

Abstract

The article is devoted to the determination of bacterial contamination and antimicrobial protection of the oral cavity in patients with oncology of the oral cavity and also in healthy persons. The study was performed on 38 patients (20 men and 18 women) with stage I-III oral cancer. The average age of patients was 56.5 years (from 33 to 75). To determine the indicators of the norm, a group of norms, including 10 subjects without changes in the oral mucosa, was created. The average age was 29.9 years (26 to 33), both sexes (6 men and 4 women) being represented. Catalase, urease, lysozyme and malonic dialdehyde (MDA) activity was determined. According to the ratio of catalase activity and MDA content, the antioxidant-prooxidant index (API) was calculated and, according to the ratio of relative activities of urease and lysozyme, the degree of dysbiosis was determined by the method of A.P. Levitsky.The study was performed on day 2 of hospitalization and day 14 of treatment. In the experimental group, correction of local immunity was performed.The biochemical studies of oral fluid conducted on patients with tumors of the oral cavity demonstrate the high effectiveness of the proposed local treatment. Thus, under its influence, in the oral cavity of patients, a decrease in the intensity of lipid peroxidation (MDA content), reduction of microbial contamination (urease activity) and of the degree of dysbiosis, with a simultaneous increase in nonspecific antimicrobial protection (lysozyme activity) and antioxidant system, were observed.