Modern aspects of diagnostics and treatment of post-infectious cough hypersensitivity syndrome

Abstract

Problem statement: search for new methods of treatment of post-infectious cough hypersensitivity syndrome is a very topical problem of practical medicine. Study objective: to optimize the treatment of patients with postinfectious cough hypersensitivity syndrome. Materials and Methods: The study included 66 patients with post-infectious cough hypersensitivity. All the patients were prescribed antitussive drugs. Patients in the main group (n = 33) additionally underwent nebulizer therapy with 0.1 % solution of hyaluronic acid twice a day and the treatment cycle involved 12–16 sessions. The final points of the study were: improvement of quality of life indicators, achievement of the state of subjective health by the patients, reduction of terms of temporary disability of patients with postinfectious cough hypersensitivity syndrome. Outcomes. Full remission of post-infectious cough hypersensitivity syndrome was achieved in all patients of the main group (р < 0.001) as a result of the conducted treatment, with disappearance of clinical manifestations, development of responses of calm and increased activation of adaptive responses of the organism. In 52 % of persons from the comparison group (р < 0.01) showed a decrease in clinical manifestations of disease signs on the background of stress, pereactivation response or poor adaptation which corresponded to incomplete remission. Conclusions: Rational combination of drugs and nebulizer way of introduction of hyaluronic acid allows to remove the symptoms of disease within a short term, restore the patient’s quality of life, achieve full remission of post-infectious cough hypersensitivity syndrome.