Стандартизований екстракт артишоку: фізіологічні ефекти, можливості використання в лікарській практиці

Abstract

Recently, among general practitioners – family doctors, therapists, specialists, there is a growing interest to the use of phyto-therapy for the prevention and treatment of various pathologies. One of the classic examples of a medicinal plant with a long history of human use is the Spanish Artichoke. The objective: to analyze the results of pharmacokinetic and pharmacodynamic studies of standardized artichoke extract (SAE)/Materials and methods. The review of the modern scientific literature publications about the properties of artichoke and pos-sible areas of its use in medical practice is performed. Results. The presented results of experimental studies confirmed that SAE is one of the safest phytopreparations, which has almost no side effects in most subjects. In a number of cases, the data of experimental pharmacology is confirmed by the results of clinical studies of evidence-based medicine. Among the effects that have been established in animal models and confirmed in clinical trials should be noted: hepatoprotective, choleretic, detoxification, prebiotic, cardioprotective, lipid-lowering, nephro-protective, carcinopreventive, gravidoprotective, etc. Conclusion. The described effects allow the use of standardized artichoke leaf extract (dried water extract of the artichoke leaves, which has a positive clinical history in both Ukraine and Europe) as an addition to the traditional therapy for the pre-vention and treatment of gastrointestinal pathology, kidney diseases, hypercholesterolemia and other pathology