Antimicrobial activity of antiseptics in the prevention ofpostoperative infectious complications

Abstract

Recently, among hospital strains of microorganisms, an increase in the number ofantiseptic-resistant strains of opportunistic pathogens has been registered, whichsignificantly affects the effectiveness of these drugs. It is important to study theirantimicrobial efficacy to justify rational use. The aim is to conduct a comparative studyof the antimicrobial efficacy of antiseptics of decamethoxine, chlorhexidine,polyhexanide. During study we examined the antimicrobial activity against 186 clinicalstrains of microorganisms (Acinetobacter baumannii, Staphylococcus aureus,Pseudomonas aeruginosa, Enterococcus spp., Enterobacter spp.) isolated from patientswith infectious complications in the postoperative period. The minimum inhibitory (MIC)and bactericidal concentrations (MBC) of 0.02 % and 0.1 % decamethoxine, 0.05 %chlorhexidine bigluconate, 0.1 % polyhexanide were determined; antimicrobial efficacyof drugs was evaluated by the index of antiseptic activity by conventional methods. Thestudy found high antimicrobial properties of decamethoxine, chlorhexidine, which hada high bactericidal effect on clinical strains of S. aureus, Enterococcus spp.,Enterobacter spp. Proved the benefits of antimicrobial activity of the drug based ondecamethoxine (p<0.001). The polyhexanide has pronounced antimicrobial propertiesagainst A. baumannii, bacteria of the family Enterobactericae, P. aeruginosa. Thus, theleading gram-positive (Staphylococcus aureus, enterococci) and gram-negativepathogens (enterobacteria, acinetobacteria, pseudomonads) are sensitive topolyhexanide, chlorhexidine and the domestic drug decamethoxin, with a probableadvantage of the antimicrobial properties of the latter over all gram-positive and mostgram-negative microorganisms.