Короткий опис (реферат):
Problem of scorpion envenomation becomes more alarming each year. Main effects of scorpion venom are
commonly believed to be related to its neurotoxic properties, yet severe symptoms may also be developed due to
the uncontrolled enzymatic activity and formation of various bioactive molecules, including middle-mass mol ecules (MMMs). MMMs are considered as endogenous intoxication markers, their presence may indicate multiple
organ failure. Scorpions, belong to the Leiurus macroctenus species, are very dangerous, nevertheless, effects of
their venom on protein and peptide composition within the tissues remains unclear. In this work we have focused
the attention on changes in protein and MMM levels and peptide composition in various organs during Leiurus
macroctenus envenomation. The results revealed a decrease in protein level during envenomation as well as a
significant increment of MMM210 and MMM254 levels in all assessed organs. Quantitative and qualitative com positions of various protein and peptide factions were continually changing. All of this may suggest that Leiurus
macroctenus sting causes considerable destruction of cell microenvironment across all essential organs, providing
systemic envenomation. In addition, MMM level increment may indicate endogenous intoxication development.
Peptides, formed during envenomation, may possess various bioactive properties, analysis of which constitutes
an area of further studies.
