Effect of H2S metabolism modulators on the level of galectin-3 in aorta, heart and kidneys of rats with streptozotocin-induced diabetes mellitus

Abstract

Diabetes mellitus (DM) is often comorbid with developing angiopathy, cardiomyopa thy and nephropathy. Іmmune-inflammatory activation of the endothelium, cardiac and renal fibrosis following chronic hyperglycemia can be linked to impaired production of hydrogen sulphide (H2S) and galectin-3. The causal relation between these factors remains disputable. Aim of the research was to evaluate the connection between changes in H2 S system and the level of galectin-3 in the blood and tissues (aorta, heart and kidneys) of rats with streptozotocin-induced diabetes mellitus. It is established that streptozotocin-induced diabetes mellitus is associated with the increase in galectin-3, the decrease in H2S, the decrease in the activity and expression of cystathionine-γ-liase (CSE) in blood, aorta, heart and kidney. The decline in the activity of H2S / CSE system is accompanied by a significant increase in galectin-3 in blood and tissues which can accelerate the development of diabetes-associated organ dysfunction and angiopathy.