The need to administer antibiotic therapy for septic shock during transportation to the emergency department for more than 1 hour

Abstract

The article compares different views on empirical antibiotic therapy during the first hour from the onset of suspected septic shock to the patient's transportation to the emergency department. The article is based on protocols and clinical guidelines from the Ministry of Health of Ukraine (MoH), Infectious Diseases Society of America (IDSA), and Society of Critical Care Medicine (SCCM). The aim of the study is to determine the feasibility of antibiotic therapy for septic shock within the first hour of its onset based on studies by foreign authors, comparison of protocols and clinical guidelines from the Ministry of Health of Ukraine (MoH), Infectious Diseases Society of America (IDSA) and Society of Crirtical Care Medicine (SCCM). To determine the optimal antibiotic regimen to prevent patient death based on the recommendations of the Ministry of Health of Ukraine and the Society of Critical Care Medicine (SCCM). The following methods were used in the study: content analysis, comparative analysis and systematization of the research material. The study was conducted based on the study of clinical guidelines and protocols of the Ministry of Health of Ukraine (MoH), Infectious Diseases Society of America (IDSA) and Society of Criminal Care Medicine (SCCM), as well as publications of foreign authors. The search was conducted on the basis of PubMed and Google Scholar databases in 2017-2023. According to the results of many scientists from around the world Ferrer R. (2014), Liu V. (2017), Singer M. (2017), Sherwin R. and co-authors (2017), Bloos F. (2017), Johnston A. (2017), Whiles B. (2017), Kim R. (2018), Sung W. (2020), Rothrock S. (2020), Sankar J. (2021), Asner S. (2021), Al-Kader D. (2022) Bisarya R. (2022) found that each additional hour of delayed antibiotic administration from triage to drug administration leads to an 8% to 34% increase in mortality among patients with septic shock before drug administration. Patients with a suspected septic process should receive antibiotics as soon as possible after diagnosis, otherwise the chances of complications in the form of septic shock increase with each passing hour. Antibiotic therapy for suspected sepsis or septic shock should be started as early as possible, but the recommendations of the IDSA and other studies should also be taken into account to reduce complications and deaths caused by septic shock.