dc.contributor.author |
Taran, O. |
en |
dc.contributor.author |
Konkov, D. |
en |
dc.contributor.author |
Klivak, V. |
en |
dc.contributor.author |
Muntian, O. |
en |
dc.date.accessioned |
2024-03-27T11:21:16Z |
en |
dc.date.available |
2024-03-27T11:21:16Z |
en |
dc.date.issued |
2024 |
|
dc.identifier.citation |
The features of the prevention of preeclampsia in pregnant women with gestational endotheliopathy in the first trimester / O. Taran, D. Konkov, V. Klivak, O. Muntian // The proceeding of the 5th International Congress on Maternal Hemodynamics, Florence, 7–9 March 2024. – Florence, 2024. – P. 7. |
en |
dc.identifier.uri |
https://dspace.vnmu.edu.ua/123456789/6527 |
en |
dc.description.abstract |
Low-dose aspirin (ASA) has been used during pregnancy, most commonly to prevent or delay the onset of preeclampsia. The Ukrainian National clinical guideline (2022) recommending daily 100-150mg from 12 weeks of gestation and continued until 35-36 weeks for women with highest risk development of preeclampsia. Most of the entheliotropic drugs are either not recommended during pregnancy due to a lack of reliable data about the absence of teratogenic and embryotoxic effects (resveratrol, meldonium), or are only undergoing clinical trials (statins proton pump inhibitors, metformin), or raise concerns about a possible link between prenatal exposure and neonatal death from pulmonary hypertension (sildenafil). In addition, all of the above drugs have a stimulating effect on the endothelium, which leads to the production of NO, but also to endothelial depletion. Therefore, it is very important to use a NO precursor from which the endothelium can synthesize the necessary substances. Thus, there is a need for a class of endothelioprotective agents that not only stimulate the endothelium to produce NO but also supply the substrate. The only substance that is a substrate for NO synthesis is L-arginine. |
en |
dc.language.iso |
en_US |
en |
dc.subject |
pregnancy |
en |
dc.subject |
preeclampsia |
en |
dc.subject |
gestational endotheliopathy |
en |
dc.subject |
Low-dose aspirin |
en |
dc.subject |
L-arginine |
en |
dc.subject |
placental dysfunction |
en |
dc.title |
The features of the prevention of preeclampsia in pregnant women with gestational endotheliopathy in the first trimester |
en |
dc.type |
Theses |
en |