Репозиторий Винницкого национального медицинского университета имени Н. И. Пирогова

Determination of CCL2 / MCP-1 levels in the serum of children with melanocytic nevus in the postoperative period after using different methods of surgical treatment

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dc.contributor.author Pasichnyk, O. en
dc.contributor.author Konoplitskyi, V. en
dc.contributor.author Korobko, Yu. en
dc.contributor.author Nazarchuk, O. en
dc.contributor.author Dmyrtriiev, D. en
dc.contributor.author Babina, Yu. en
dc.date.accessioned 2022-11-14T20:41:34Z
dc.date.available 2022-11-14T20:41:34Z
dc.date.issued 2022
dc.identifier.citation Determination of CCL2 / MCP-1 levels in the serum of children with melanocytic nevus in the postoperative period after using different methods of surgical treatment / O. Pasichnyk, V. Konoplitskyi, Yu. Korobko [et al.] // Acta Biomed. - 2022. - Vol. 93, № 2. - P. e2022058. - DOI: 10.23750/abm.v93i2.12226. en
dc.identifier.uri https://dspace.vnmu.edu.ua/123456789/5807
dc.description.abstract To date, there are many methods and ways to remove pigmented skin tumors, which have their own indications and contraindications for use, early or late complications. The aim of the study was to determine the level of CCL2 / MCP-1 in the serum of patients with melanocyte skin nevi in the postoperative period with different methods of their removal. Materials and methods of research. The study involved 60 children with melanocyte skin nevi of different localization, who were hospitalized in the pediatric surgery clinic in the period from 2018 to 2020. All patients were divided into 3 groups : I group - the excision of the formation took place with a scalpel, group II - excision of the formation was performed using a high-intensity surgical laser, group III - excision of the formation using a high-frequency electrosurgical device «BOWA-ARC 350. Results and discussion. The results of our study showed an increase in the level of CCL2 / MCP-1 plasma level in the patients of group I in 2,6 times in 12 hours after surgery and in 3,15 times in 24 hours after surgery. A similar but more pronounced dynamics of CCL2 / MCP-1 plasma level was observed in patients of group II. The largest increase in CCL2 / MCP-1 levels was observed in the comparison group III. Conclusions. High CCL2 / MCP-1 plasma level in patients of groups II and III in 12 and 24 hours after surgery convincingly indicate the presence of a pronounced inflammatory reaction under the influence of thermal damaging factor on skin tissues. en
dc.language.iso en en
dc.publisher Acta Biomed en
dc.subject children en
dc.subject pigmented nevi en
dc.subject CCL2 / MCP-1 level en
dc.subject operation en
dc.title Determination of CCL2 / MCP-1 levels in the serum of children with melanocytic nevus in the postoperative period after using different methods of surgical treatment en
dc.type Article en


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