Structural and functional changes of cardiovascular system in children with asthma

Abstract

Rhythm disturbances in the form of sinus tachycardia was detected in 30.6 % of children with UC BA, and it was significantly more frequent compared to the children with C BA – 8.05 % (P < 0.01) and the control group – 6.06 % (P < 0.001). Bradycardia occurred significantly more often in those with uncontrolled BA (19.3 %) compared to the control group (3.03 %) and the patients with C BA (8.5 %), P < 0.05. Supraventricular extrasystoles were detected significantly more often in the children with UC BA (29.0 %) compared to those with C BA (8.5 %, P < 0.01). In the children with UC BA serum K+ was significantly lower compared to the control group, the children with C BA and PC BA (P < 0.001). In the children with well controlled BA serum K+ level was also significantly decreased compared to the control group and those with C BA (P < 0.01). The analysis of the blood serum K+ level to that in erythrocytes ratio showed that 32.2 % of children with UC BA and 13.3 % of those with PC BA (P < 0.05) had hypokalemia. Hypokalihistia was found in 18.5 % of the children with UC BA and 10.0 % of those with PC BA (P < 0.05). Total serum LDH level was found to be significantly increased in the children with UC BA compared to the control group, children with C BA (P < 0.001) and PC BA (P < 0.01). Thus, in the children with UC BA total CPK was significantly higher compared to the control group, the children with C BA (P < 0.001) and PC BA (P < 0.01). Patients with uncontrolled bronchial asthma commonly have functional cardiovascular disorders, decreased K+ level in blood serum and erythrocytes as well as increase in total CPK, isoenzyme CPK–MB, total lactate dehydrogenase and lactate dehydrogenase isoenzyme 1.