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dc.contributor.author | Malachkova, N. V. | en |
dc.contributor.author | Yatsenko, D. A. | en |
dc.contributor.author | Ljudkevich, G. P. | en |
dc.contributor.author | Shkarupa, V. M. | en |
dc.date.accessioned | 2020-01-17T13:23:07Z | |
dc.date.available | 2020-01-17T13:23:07Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Polymorphism of TGF-β1 (rs1800469) in children with different degrees of myopia / N. V. Malachkova, D. A. Yatsenko, G. P. Ljudkevich, V. M. Shkarupa // Journal of Ophthalmology (Ukraine). - 2018. - № 5 (484). - Р. 45-48. | en |
dc.identifier.uri | https://dspace.vnmu.edu.ua/123456789/4280 | |
dc.description.abstract | Background: TGF-β is a key intrascleral mediator of extracellular matrix remodeling. Purpose: To investigate the pattern of allele frequency and genotype distribution for TGF-β1 gene rs1800469 among the Ukrainian Podillia region’s pediatric population with different degrees of myopia. Materials and Methods: Real-time polymerase chain reaction was used for genotyping for TGF-β1 gene rs1800469 in 105 children (210 eyes) with different degrees of myopia and 107 emmetropic children. Results: Compared to controls, signifcant differences in allele and genotype frequencies for the SNP under investigation were found only in the high myopia group. The presence of the C allele of TGF-β1 -509 C>T (rs1800469) was found to increase the risk for developing high myopia (OR = 2.44, 95% CI, 1.17–5.08; p = 0.02). The presence of a variant T allele was found to have an additive protective effect against developing high myopia in the CT genotype carriers (OR = 0.85, 95% CI, 0.34–2.16; p = 0.02) and TT genotype carriers (OR = 0.16; 95% CI, 0.02–1.29; p = 0.02). Conclusion: To our best knowledge, this study is the frst to demonstrate that the CC genotype of rs1800469 is associated with the risk of the development of high myopia in a European population. | en |
dc.language.iso | en | en |
dc.subject | myopia | en |
dc.subject | sclera | en |
dc.subject | TGF-β1 | en |
dc.subject | polymorphism | en |
dc.title | Polymorphism of TGF-β1 (rs1800469) in children with different degrees of myopia | en |
dc.type | Article | en |