dc.contributor.author |
Malachkova, N. V. |
en |
dc.contributor.author |
Yatsenko, D. A. |
en |
dc.contributor.author |
Ljudkevich, G. P. |
en |
dc.contributor.author |
Shkarupa, V. M. |
en |
dc.date.accessioned |
2020-01-17T13:23:07Z |
|
dc.date.available |
2020-01-17T13:23:07Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
Polymorphism of TGF-β1 (rs1800469) in children with different degrees of myopia / N. V. Malachkova, D. A. Yatsenko, G. P. Ljudkevich, V. M. Shkarupa // Journal of Ophthalmology (Ukraine). - 2018. - № 5 (484). - Р. 45-48. |
en |
dc.identifier.uri |
https://dspace.vnmu.edu.ua/123456789/4280 |
|
dc.description.abstract |
Background: TGF-β is a key intrascleral mediator of extracellular matrix
remodeling. Purpose: To investigate the pattern of allele frequency and genotype distribution for TGF-β1 gene rs1800469 among the Ukrainian Podillia region’s pediatric population with different degrees of myopia.
Materials and Methods: Real-time polymerase chain reaction was used
for genotyping for TGF-β1 gene rs1800469 in 105 children (210 eyes) with different degrees of myopia and 107 emmetropic children.
Results: Compared to controls, signifcant differences in allele and genotype frequencies for the SNP under investigation were found only in the high myopia group. The presence of the C allele of TGF-β1 -509 C>T (rs1800469) was found to increase the risk for developing high myopia (OR = 2.44, 95% CI, 1.17–5.08; p = 0.02). The presence of a variant T allele was found to have an additive protective effect against developing high myopia in the CT genotype carriers (OR = 0.85, 95% CI, 0.34–2.16; p = 0.02) and TT genotype carriers (OR = 0.16; 95% CI, 0.02–1.29; p = 0.02).
Conclusion: To our best knowledge, this study is the frst to demonstrate that the CC genotype of rs1800469 is associated with the risk of the development of high myopia in a European population. |
en |
dc.language.iso |
en |
en |
dc.subject |
myopia |
en |
dc.subject |
sclera |
en |
dc.subject |
TGF-β1 |
en |
dc.subject |
polymorphism |
en |
dc.title |
Polymorphism of TGF-β1 (rs1800469) in children with different degrees of myopia |
en |
dc.type |
Article |
en |