The remodeling of left atrium and vasodilation factors changes in ischemic heart failure

Abstract

Background. According to the national registries of European countries and epidemiological studies, the prevalence of chronic heart failure (CHF) among adults is 2,0–5,0%, and increases due to age, in people aged over 70 years old it is 10,0–20,0%. Objective. To find out the specific features of remodeling of the left atrium and change of vasodilation factors in ischemic heart failure with reduced and preserved left ventricular ejection fraction and to establish correlation relationships. Methods. A full clinical examination of 153 patients with CHF (105 men and 48 women) was conducted to achieve this objective. The surveyed patients underwent clinical examinations; spectrophotometric parameters: quantification of markers of vasodilation, metabolites of monoxide nitrogen — nitrates and nitrites with Gris reagent; content of endothelial nitric oxide synthase (eNOS ) in serum — ELISA for the set of Nitric Oxide Synthase 3, Endothelial (NOS 3) Human ELISA Kit (Cloud-Clone Corp, USA ). Electrocardiographic (ECG ) examination was conducted in 12 standard conventional leads on electrocardiograph by the Hungarian production Heart Screen 112 D.