Features prevalence of polymorphism lle50Val gene IL4RA in patients with bronchial asthma and healthy children school age Vinnichina

Abstract

Homozygous genotype A / A Vinnichiny among school children suffering from asthma occurs in 4.34 times (p <0,05) more often and genotype G / G - 4.2 times (p <0,05) less compared to practically healthy children with prevalence 1.6 times allele a carriers (p <0,05), respectively, carrier genotype a / a and a allele is associated with the development of asthma and is a marker of increased risk of disease, and the presence of the genotype G / G and allele G - "unfavorable" to the development of bronchial asthma. The distribution of the frequency of genotypes for the Ile50Val polymorphism of the IL4RA gene is independent of sex and indicates a collision lshennya heterozygous genotype A / G patients among boys in 1.84 times, and among girls - by 1.3 times compared with native homozygous genotype A / A (p <0,001) and, respectively, 8.74 and 9 times - compared with a mutant genotype G / G (p <0.001).