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dc.contributor.author | Storozhenko, K. V. | en |
dc.contributor.author | Shkarupa, V. M. | en |
dc.date.accessioned | 2018-10-08T16:13:13Z | |
dc.date.available | 2018-10-08T16:13:13Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Storozhenko K. V. Association of FGFR2 (rs2981579) Gene Polymorphism with the Risk of Mesial Occlusion / K. V. Storozhenko, V. M. Shkarupa // Cytology and genetics. - 2017. - Vol. 51, No. 5. - P. 361-364. | en |
dc.identifier.uri | https://dspace.vnmu.edu.ua/123456789/3079 | |
dc.description.abstract | The molecular-genetic testing of the polymorphic rs2981579 (C>T) locus of the FGFR2 gene as the marker of increased predisposition to the development of mesial occlusion was carried out in 110 patients with mesial occlusion and 103 general-population control subjects from Ukraine. It was shown that polymorphism rs2981579 in gene FGFR2 is associated with mesial occlusion (OR = 1.67, 95% CI = 1.14–2.45, p = 0.009). Compared to CC carriers, TT+CT carriers had a 3.21-fold higher risk of mesial occlusion (95% CI = 1.57–6.57, p = 0.001). We found the protective effect of the homozygous allele C on mesial occlusion development (OR = 0.31, p = 0.001). This is the first published data on FGFR2 polymorphisms rs2981579 (C>T) in patients with mesial occlusion. | en |
dc.language.iso | en | en |
dc.subject | mesial occlusion | en |
dc.subject | gene polymorfism | en |
dc.subject | FGFR2 | en |
dc.title | Association of FGFR2 (rs2981579) gene polymorphism with the risk of mesial occlusion | en |
dc.type | Article | en |