https://dspace.vnmu.edu.ua/123456789/241 статті, матеріали конференцій Tue, 07 Apr 2026 18:12:21 GMT 2026-04-07T18:12:21Z https://dspace.vnmu.edu.ua/123456789/11631 Clinical-epidemiological characteristics of acute bacterial meningitis in children of Khmelnitskyi region (Podilsky region, Ukraine): fifteen-year-long Pypa, L. V.; Lysytsia, Ju. N.; Polishchuk, D. S.; Svistilnik, R. V.; Romanchuk, K. Yu. Acute bacterial meningitis (ABM) leads to a significant number of complications and high mortality. The aim — to analyze the etiological structure, epidemiological, socio-demographic features and complications in ABM in children of Khmelnitskyi region during 2004–2018. Materials and methods. The analysis of 346 cases of ABM, of which 217 boys and 129 girls was conducted. The etiology of meningitis was determined by bacterioscopy, bacteriological sowing, latex agglutination and polymerase chain reaction. Complications were revealed analytical method, t-criterion and constructing 95% confidence interval. Results. The disease started with fever 346 (100%), neck stiffness 289 (83.5%) and vomiting 273 (78.9%), less common, alteration of consciousness 28 (8.1%) and seizures 9 (2.6%). The high level of the cytosis were observed in meningococcal (5801.3±4856.7 cells/mm3) and Hib meningitis (5152.6±4153.1 cells/mm3), the lowest level was in pneumococcal meningitis (2601.0±1839.6 cells/mm3). The highest level of liquor protein was in pneumococcal meningitis (179.0±51.0 mg/dl), and the lowest level was in meningococcal meningitis (102.0±49.0 mg/dl) and Hib meningitis (112.0±56.0 mg/dl). The etiological factor was established in 121 (35.0%) of patients. 52 (15.4%) of patients had neurological complications. Conclusions. The majority (58.1%) of ABM are in children under the age of 3. The main causative agent remains N. meningitidis — 57.9%, the second place is S. pneumoniae — 21.5%, the third Hib — 9.9% of cases. Frequent complications were brain edema 32 (61.5%), seizures 19 (36.5%) and hydrocephalus 8 (15.4%). The study was conducted in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of the children’s parents was obtained for the research. Sat, 01 Jan 2022 00:00:00 GMT https://dspace.vnmu.edu.ua/123456789/11631 2022-01-01T00:00:00Z https://dspace.vnmu.edu.ua/123456789/11630 Clinical-epidemiological characteristics of aseptic meningitis in children of khmelnitskyi region (Podilskyi region, Ukraine): fourteen-year epidemiological observation Pypa, L. V.; Svistilnik, R. V.; Lysytsia, Yu. N.; Romanchuk, K. Yu.; Odarchuk, I. V. Aim of work – to analyze the etiological structure, epi demiological structure, social-demographic features and the nature of the development of complications of the central nervous system in aseptic meningitis in children in Khmel nitskyi region for the period 2004-2017. Materials and methods. It was conducted a prospective analysis of 208 cases of aseptic meningitis in children of whom 138 people were boys and 70 people were girls. The etiology of the disease was determined by studying cerebro spinal fluid using PCR method. Complications of the central nervous system were diagnosed on the basis of the clinical picture and CT or MRI scans. The analytical method was used to conduct the analysis of the received data. Results. The highest seasonal increase of the incidence was from August to October and it was 65.6% with its peak in September (24.0%). The clinical picture was characterized by a moderate trend in 71.2% of cases and in 28.8% by a se vere course. In 100% of cases the disease began with a fever, headache (83.6%), vomiting (76.9%), abdominal pain with diarrhea (6.2%), epileptic seizures (0.9%). The average level of cytosis was 269.4±196.7 cells/mm3 with a predominance of lymphocytes and the average protein level in cerebrospinal fluid was 73 ± 36 mg/dl. The etiological factor was estab lished in 18 (8.6%) patients. Conclusions. Enterovirus remains to be the main patho gen which was determined in 72.2% of cases. The second place was taken by herpes viruses (22.2% of cases), the third place was given to the mumps virus (5.6% of cases) (in etio logically verified cases). In most cases the disease ended in complete recovery but in 47 (22.6%) patients the complica tions were observed. The prevalence of aseptic meningitis among children in Khmelnitskyi region was 6.2 per 100,000 children, and males outnumbered females by a 2:1 ratio. Tue, 01 Jan 2019 00:00:00 GMT https://dspace.vnmu.edu.ua/123456789/11630 2019-01-01T00:00:00Z https://dspace.vnmu.edu.ua/123456789/11479 IFNL4 polymorphism as a predictor of chronic hepatitis C treatment efficiency in ukrainian patients Kucherenko, A. M.; Pampukha, V. M.; Romanchuk, K. Yu.; Chernushyn, S. Yu.; Bobrova, I. A.; Moroz, L. V.; Livshits, L. A. The aim of this study was to examine association between IFNL4 gene ss469415590 and treatment efficiency in group of Ukrainian PEG-interferon/ribavirin-treated chronic hepatitis C patients. Study group consisted of 92 unrelated hepatitis C virus genotype 1 mono-infected patients: case group – 29 patients with late or absent virological response; control group – 63 patients with sustained virological response. Study material was genomic DNA. Genotyping was performed using amplification-refractory mutation system PCR. Statistical analysis was performed using GenePop and OpenEpi statistical packages. Obtained results show that ss469415590 ΔG/ΔG genotype is associated with poor virological response (OR = 3.62; CI 95%: 1.12–11.67) in PEG-interferon/ribavirin-treated chronic hepatitis C patients from Ukraine Fri, 01 Jan 2016 00:00:00 GMT https://dspace.vnmu.edu.ua/123456789/11479 2016-01-01T00:00:00Z https://dspace.vnmu.edu.ua/123456789/11457 Впровадження методу Clinical Case Discussion (CCD) у освітній процес на кафедрі інфекційних хвороб Романчук, К. Ю.; Андросова, О. С.; Бондарук, І. Ю.; Житнюк, Н. В. Wed, 01 Jan 2025 00:00:00 GMT https://dspace.vnmu.edu.ua/123456789/11457 2025-01-01T00:00:00Z