Наукові публікації каф. внутрішньої медицини

Electromyographic complex with goniometric tracking of the degree of muscle

2021-01-01T00:00:00Z

Electromyographic complex with goniometric tracking of the degree of muscle Zhemchuzhkina, Tatyana V.; Kostin, Denys O.; Prisych, Olena Yu.; Palii, Irina K.; Kovalskiy, Viktor P.; Gromaszek, Konrad; Amirgaliyeva, Saltanat; Kozbakova, Ainur; Nosova, Tatyana V. The focus of this research is on the upgrade of the electromyographic system of diagnosing back pain. Back pain is a common ailment that affects people of different classes and differs in its intensity. The evaluation of the condition of the back muscles is carried out according to the results of an electromyographic examination during physical exercise. Electromyographic results are strongly correlated with the degree of tension and flexion of the muscle. The quality of the physical exercise by the patient can be determined by the presence of pain or fear of pain. In this regard, it is proposed to supplement the electromyographic complex with blocks of control of the level of pain, degree of flexion of the back muscles, and sound stimulus to maintain maximal back flexion.

Досвід впровадження інформаційних технологій в процесі вивчення клінічної дисципліни у вищому медичному навчальному закладі

2021-01-01T00:00:00Z

Досвід впровадження інформаційних технологій в процесі вивчення клінічної дисципліни у вищому медичному навчальному закладі Пашкова, Ю. П.; Палагнюк, Г. О.; Матохнюк, М. О. Представлена стаття дає можливість розглянути результати впровадження технологій дистанційного навчання у навчальний процес студентів Вінницького національного медичного університету імені М.І. Пирогова опановуючи навчальну дисципліну «Внутрішня медицина». На сьогоднішній день стрімко зростає кількість інформації, яка так необхідна для отримання, розуміння і засвоєння знань. Враховуючи сучасний темп розвитку освіти, на сьогодні досить актуальним є пошук інноваційних форм якісної організації навчального процесу. Саме це і призвело до впровадження інформаційних технологій в освіту і формування окремого виду навчання – дистанційного. Нині в Україні на всіх рівнях освіти широкого розвитку набуває дистанційна форма навчання, що надає можливість індивідуалізувати процес набуття знань, умінь, навичок і способів пізнавальної діяльності людини, який відбувається, в основному, за опосередкованої взаємодії віддалених один від одного учасників навчального процесу у спеціалізованому середовищі, що функціонує на базі сучасних інформаційно-комунікаційних технологій.

Clinical significance of single nucleotide missense-mutation rs950880 of the IL1RL1 gene in patients with essential hypertension

2021-01-01T00:00:00Z

Clinical significance of single nucleotide missense-mutation rs950880 of the IL1RL1 gene in patients with essential hypertension Bahrij, D. A. Modern cardiology requires the search for specific pathogenetically involved genemutations, the consequences of which can be considered in the management of patientswith hypertension. Scientists are targeting C/A polymorphism at the rs950880 position,which is associated with tissue expression of the IL1RL1 gene and the plasma level ofsoluble ST2 - a new biomarker in the diagnosis of cardiovascular disease. The aim ofthe study was to evaluate the association of rs950880 polymorphism of the IL1RL1 geneand the state of central and intracardiac hemodynamics in men with essentialhypertension (EН) of varying severity, residents of the Podillia region of Ukraine. 170men who met the inclusion criteria were examined according to a standard protocol,which included clinical, laboratory and instrumental examinations in accordance withcurrent recommendations. The subjects were divided into a control group of 70 menwithout cardiovascular disease and a study group of 50 men with asymptomatic EН and50 people with EH complicated by IIA stage chronic heart failure (CHF). Genotyping ofSNP rs950880 of the IL1RL1 gene was performed using an allele-specific polymerasechain reaction. All men in the control group and the study group underwent echocardiographywith Doppler according to the standard protocol. Statistical processing of the obtainedresults was performed in the package Statistica 12.0 using conjugation tables analysis,analysis of variance. It was found that among men living in Vinnytsia, Ukraine, carriers ofСС and CA SNP rs950880 of the IL1RL1 gene dominate (42.35 % and 45.30 % ofindividuals, respectively), AA homozygotes are significantly less common (12.53 %,p<0.05). Men without cardiovascular diseases and patients with EH do not differ significantlyin the frequency of different variants of the genotype of the studied gene. C\A polymorphismis not associated with the risk of EН. The homozygotes AA with EH have a significantlylower LV myocardial mass index (LVMMI) (69.14±6.90 g/m2.7, compared with homozygotesCC - 75.42±2.54 g/m2.7, and heterozygotes CA - 76.96±3.18 g/m2.7, p<0.05). Among thecarriers of the C allele, an "unfavorable" EН phenotype is mainly formed in the form of ahigh risk of LV hypertrophy (OR=11.36, 95 % СI=0.63-24.76, χ2=14.32, p=0.0008).Homozygotes AA in the rs950880 locus of the IL1RL1 gene, on the contrary, have a lowprobability of developing LV hypertrophy (OR=0.80, 95 % SI=0.02-0.42, χ2=14.32, p=0.0008)and its preserved systolic function. Thus, the SNP rs950880 of the IL1RL1 gene is notassociated with the risk of EH or its severity in residents of Vinnytsia, Ukraine. Carriageof the C allele is accompanied by the formation of an "unfavorable" EH phenotype with asignificantly high risk of LV hypertrophy.

The effect of ademol on the dynamics of s100 proteins in rats with traumatic brain injury

2022-01-01T00:00:00Z

The effect of ademol on the dynamics of s100 proteins in rats with traumatic brain injury Semenenko, Sviatoslav; Semenenko, Andrii; Saienko, Andrii; Semenenko, Natalia; Konovalova, Nina; Babina, Yuliana; Nazarchuk, Halyna Currently:the problem of choosing an effective drug approach for cerebroprotection, in case of traumatic brain injury (TBI), remains to be poorly understood. Clinical studies of cerebroprotectors -antagonists of NMDA-receptors indicate the feasibility of their use in practice. In our opinion, for further research, it would be correct to choose a compound that has neuroprotective properties and synthesized under the guidance of Academician M.O. Lozynsky at theInstitute of Organic Chemistry of the National Academy of Sciences of Ukraine, a derivative of 1-adamantylethyloxy-3-morpholoin-2-propanol hydroxide (Ademol). Materials and Methods:The pharmacological action of Ademol was investigated on the example of a simulated TBI at a dose of 2 mg/kg intravenously every 12 hours for 8 days. The control group and pseudooperated animals received NaCl 0,9% at a dose of 2 mg/kg intravenously (i/v), the comparison group received Amantadine sulfate 5 mg/kg. To determine the efficiency and activity of these molecules the activity of the protein S 100 was used. Results:The dynamics of S 100 protein levels in groups of rats with Ademol and Amantadine sulfate with traumatic brain injury on the 8th day of observation indicates that on the background of the above therapy, the content of the studied marker decreased by an average of 50,8 and 39.9%. Treatment of rats with severe traumatic brain injury with Ademol at a dose of 2 mg/kg (i/v), was probably better than treatment of rats in the control group with saline and amantadine sulfate and better helped to reduce the growth of protein S 100 level, while Ademol exceeded the reference drug at 18,2% (p <0.05).