https://dspace.vnmu.edu.ua/123456789/138 статті, матеріали конференцій 2026-04-12T01:28:50Z https://dspace.vnmu.edu.ua/123456789/11026 Сучасні наукові підходи до лікування хвороби Альцгеймера: ефективність антиамілоїдних моноклональних антитіл Маслій, В.П.; Голавська, Д. В. Хвороба Альцгеймера – є однією з найпоширеніших форм деменції та сягає близько 60-80% усіх випадків. За даними статистичних досліджень на 2019 рік, підтверджена кількість випадків у європейських жінок становить 6 650 228 осіб, а у чоловіків – 3 130 449 осіб, що менше в два рази, ніж у жінок. Також прогнозується, що до 2050 року загальна кількість захворювань зросте до 18 846 286 осіб, що у 1,92 рази від даних 2019 року). При цьому, показник хвороби Альцгеймера серед причин смерті дорослого населення в Україні становить 0,3 на 100 000 населення. У той час, як у Великобританії цей показник становить 112 на 100 000 осіб, у США – 82, у Франції – 76, у Німеччині – 51 2025-01-01T00:00:00Z https://dspace.vnmu.edu.ua/123456789/11024 Патогенез хвороби Паркінсона Маслій, В.П.; Демко, А. О. Хвороба Паркінсона — поширений нейродегенеративний розлад, який характеризується тріадою моторних симптомів: ригідність, тремор, брадикінезія із постуральною нестабільністю. Окрім моторних проявів, хвороба Паркінсона також супроводжується немоторною симптоматикою, яка може розвиватися раніше моторної на декілька років чи десятиліть. До таких симптомів належать біль, розлади сну, вегетативна дисфункція, порушення нюху, когнітивні та психічні розлади. 2025-01-01T00:00:00Z https://dspace.vnmu.edu.ua/123456789/11022 Skinfold thickness in Ukrainian men and women with multiple sclerosis Gunas, M. M. bnormalities in adipose tissue metabolism often accompany the progression of neurodegenerative disorders. Anthropometric body measurements may serve as additional markers of disease severity and disease course. Studying these measurements may provide a deeper understanding of the systemic changes that occur in the setting of demyelination. The aim of the study is to determine the characteristics and sex differences of skinfold thickness in young Ukrainian men and women with multiple sclerosis with varying degrees of disability. Skinfold thickness was determined in 35 Ukrainian men and 59 women with multiple sclerosis with mild, moderate and moderately severe impairments. The initial skinfold thickness measurements of 82 practically healthy Ukrainian men and 101 women of similar age were taken from the data bank of the National Pirogov Memorial Medical University, Vinnytsya Research Center. Statistical analysis was performed in the licensed package «Statistica 6.0» using nonparametric evaluation methods. When comparing skinfold thickness between practically healthy and multiple sclerosis men or women, numerous significant or trends of differences were established: in all groups of sick men and women – lower skinfold thickness values on the shin and at the lower angle of the scapula and higher skinfold thickness values on the chest; in most groups of male patients – higher values of skinfold thickness on the thigh and on the side and lower values of skinfold thickness on the back of the shoulder; in most groups of patients and women control group – higher values of skinfold thickness on the forearm and on the thigh and lower values of skinfold thickness on the abdomen. There are practically no reliable or trends in skinfold thickness differences between groups of patients with multiple sclerosis, men or women. Manifestations of sexual dimorphism between patients with multiple sclerosis are established mainly for skinfold thickness on the extremities (higher values in women). The multidirectional discrepancies in skinfold thickness on the thigh and lower leg and at the lower angle of the scapula and on the chest established between practically healthy and patients with multiple sclerosis are manifestations of a subpathological constitutional type in this disease 2025-01-01T00:00:00Z https://dspace.vnmu.edu.ua/123456789/11021 FEATURES OF TRANSVERSE BODY DIMENSIONS IN UKRAINIAN MEN AND WOMEN WITH MULTIPLE SCLEROSIS Gunas, M. M. Transverse body dimensions are an important characteristic of a person’s somatotype and may be one of the factors associated with the risk of developing multiple sclerosis. The study of these parameters in men and women allows not only to as-sess the possible relationship between morphometric features and the onset of the disease, but also to predict its potential severity. The analysis of such changes may contribute to a deeper understanding of the pathogenetic mechanisms of the development of multiple sclerosis, which, in turn, opens up opportunities for improving methods of early diagnosis and developing effective preven-tion strategies. The aim of this study is to establish the characteristics and sex differences in the transverse dimensions of the body in Ukrainian men and women with multiple sclerosis with varying degrees of disability. As a control group, the primary transverse dimensions of the body of 82 practically healthy Ukrainian men and 101 women of similar age were taken from the data bank of the National Pirogov Memorial Medical University, Vinnytsya Research Center. Statistical analysis was performed in the licensed package “Statistica 6.0” using non-parametric evaluation methods. Statistical analysis was performed in the licensed package “Sta-tistica 6.0” using non-parametric evaluation methods. When comparing the transverse dimensions of the body between practically healthy and multiple sclerosis men or women, it was found that: in all groups of sick men and women – larger values of the width of the distal epiphysis (WDE) of the forearm, transverse lower thoracic diameter and interspinous distance; in most groups of male and female patients – higher values of WDE of the tibia, transverse mid-thoracic, anteroposterior mid-thoracic diameters, shoulder width and intertrochanteric distance, as well as lower values of WDE of the thigh; in most groups of male patients – lower values of intercristal distance; in most groups of female patients – higher values of WDE of the shoulder. The lower values of WDE of the thigh established in most groups of male patients and women against the background of higher values of WDE of the tibia, as well as higher values of interspinous and intertrochanteric distance in most groups of male patients against the background of lower values of intercristal distance, are manifestations of a “subpathological” constitutional type. Between men or women with multiple sclerosis, numerous reliable or trends of differences were established only for WDE of the long tubular bones of the limbs (higher values in men with moderately severe disorders, and in women with moderate disorders). Pronounced manifestations of sexual dimorphism were found between male and female patients with multiple sclerosis for all WDE indices of long tubular bones of the limbs and most trunk diameters (higher values in men in general groups and in patients with mild and moderately severe disorders). 2025-01-01T00:00:00Z