Influence of endothelial dysfunction and perinatal factors on atopic disease in preterm children

Abstract

Atopic diseases accompanied by inflammatory disorders, morphological and functional alterations of microvessels, especially in preterm baby. Сlinical significance of endothelial dysfunction and perinatal factors in preterm infants with atopic diseases was established. Found that children with atopic diseases was significantly (p<0,05) more likely to have been born to mothers who had a history of chronic urogenital infections, abortions, miscarriages. Regression analysis established the relationship between values of serum VEGF at 5-7 day of life and indicators of body weight (r=0,62, p<0,05), duration of gestation at birth (r=0,64, p<0,05) and duration of mechanical ventilation (r=0,89, p<0,05). Several maternal characteristics, perinatal factors, VEGF level are associated with an elevated risk of atopic diseases in the child in later life.