1. Georgian Med News. 2021 Oct;(319):102-108.

ENDOTHELIAL DYSFUNCTION AND PATHOGENETIC PHENOTYPES OF LOCALIZED SCLERODERMA.

Al-Omary Obadeh M(1), Bondar S(1).

Author information:
(1)National Pirogov Memorial Medical University, Department of Skin and Venereal 
Diseases, Vinnytsia, Ukraine.

There are several pathogenetic models of localized scleroderma. At the same 
time, studies examining the role of endothelin-1, vascular endothelial growth 
factor (VEGF-A) and cell adhesion molecule-1 (VCAM) are limited. Objectives - to 
learn the nature of disorders of vascular, proliferative, adhesive functions of 
the endothelium on the content of endothelin-1, VEGF-A and VCAM-1 in localized 
scleroderma. The study included 78 patients with localized scleroderma and 35 
healthy individuals (mean age - 44.2±17.6 years, 73 women (64.6%), 40 men 
(35.4%). All patients underwent clinical, laboratory, enzyme-linked 
immunosorbent assay examination (endothelin-1, VEGF-A, VCAM-1). In the local 
form of scleroderma, there are the number of disorders of vascular, 
proliferative and adhesive functions of the endothelium, with an increase in 
endothelin-1 (p<0.05), VEGF-A (p<0.05) and VCAM-1 (p<0.05) content. In 
idiopathic atrophodermia, the level of endothelin-1 was probably higher 
(p<0.05). The vasospastic type of pathogenesis of localized scleroderma was 
established in patients under 20 years of age (p<0.05) and in patients older 
than 70 years (p<0.05). U-shaped age dependence of pathogenesis was noted: high 
content of VEGF-A in patients under 20 years of age (p<0.05) and after 35 years 
(p<0.05). Higher levels of VCAM-1 were found in women compared to men (p<0.05). 
The analysis of the age dependence of the content revealed a U-shaped dependence 
of VCAM-1 - the highest content in patients under 20 years (p<0.05) and in 
patients 55-70 years (p<0.05). The level of biomarkers of endothelial 
dysfunction in patients with localized scleroderma - endothelin-1, VEGF and VCAM 
is associated with different phenotypes of the disease course - vasospastic, 
proliferative or adhesive.

PMID: 34749332 [Indexed for MEDLINE]